Rapid Expansion of SCF Solutions : RESS

RESS: Rapid Expansion:

• Solute dissolved in SCF CO2

• Expanded to ATM

• Solubility decreases by 106

• Supersaturation, Nucleation

• Highly uniform particles

• Controllable size

GAS: Gas anti-solvent Approach

SAS: Supercritical non-solvent

• Drug dissolves in carrier solvent, not CO2

• Carrier solvent is partially miscible with CO2

• Mixing carrier with SCF causes precipitation

SC CO2 source

SC CO2

Solute

Fine Particle

CO2 gas

Solvent & Solute

Fine Particle

Previous slide

Next slide

Back to first slide

View graphic version