Goal: Online
Toxicity Testing
1.
Sample taken from online process
and injected into cell reactor
(37°C and 5% CO2)
2.
Reagents lyse cells after 6 hour
incubation. Lysate is pumped
to RNA isolation/labeling
modules.
Reactor
Pump
Microarray
3.
mRNA is isolated in the first module
then labeled in the second.
Product is then applied to the
microarray surface.
4.
Hybridization of labeled probe to target
is controlled and monitored electronically.
In about 8 hours, toxicity
of analytes is assessed.
Isolation
and Labeling
Modules