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2016 / 2017 - |
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If you are interested in
additional presentation information, contact Alicia Foley
ali@erc.arizona.edu |
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Jan. 7, 2016 |
Host: Paul Pantano,
University of Texas-Dallas
Guest speaker:
Dr. Brenner
is a preventive medicine and public health physician at the SUNY Polytechnic
Institute Colleges of Nanoscale Science & Engineering (CNSE)
Topic title:
Implications of Nanotechnology on Human and Environmental Health
Abstract:
The rapid
growth and projected acceleration of nanotechnology creates urgency in
understanding, predicting, and managing the potential health risks
associated with occupational, environmental, and consumer exposures to
nanomaterials. Dr. Brenner’s research integrates occupational and
environmental medicine, exposure science, industrial hygiene, materials
science, and metrology to investigate the potential human health and safety
implications of exposure to engineered nanomaterials. The goal is to
proactively address the emerging needs of health and safety research related
to engineered nanomaterials, seeking to develop in real-time the innovative
technologies and methodologies needed to assess, monitor, and safely
accelerate nanotechnology R&D worldwide. Some of her ongoing research
projects include exposure assessment to help define occupational and
environmental exposures to engineered nanoparticles in real-world scenarios.
These projects include assessing worker exposure to engineered nanomaterials
during semiconductor manufacturing, determining the fate of nanoparticles in
conventional wastewater treatment processes, and measuring the efficacy of
control measures in preventing occupational exposure to engineered
nanoparticles. Exposure assessment data informs realistic dosing models and
regimens for related nanotoxicology research efforts to help define hazards
using cell and animal models.
Bio (Sara Brenner, MD, MPH):Dr.
Brenner is a preventive medicine and public health physician at the SUNY
Polytechnic Institute Colleges of Nanoscale Science & Engineering (CNSE),
serving as the Assistant Vice President for NanoHealth Initiatives and an
Assistant Professor of Nanobioscience. Her research and initiatives aim to
develop novel nanotechnology applications in the life sciences, including
medicine and public health. Dr. Brenner is leading health and safety
research initiatives related to nanoparticle and nanomaterial exposures in
the workplace, consumer marketplace, and environment. She is Chair of the
steering committee for the NanoHealth and Safety Center at CNSE, a
public-private partnership that is addressing gaps in our understanding of
the safety and risk associated with the unique characteristics of nanoscale
materials. Her research team incorporates theory from many disciplines such
as physics, engineering, biology, genetics, medicine, public health,
epidemiology, industrial hygiene, and environmental science to advance risk
assessment and reduction strategies for occupational exposures, monitoring
of materials that may impact population health and public safety, and the
development of industrial practice standards for product safety. She is also
the CNSE Program Director of the MD/PhD program in medicine and nanoscale
science or engineering, a program that she helped co-found with SUNY
Downstate Medical Center. It is the first dual-degree clinical training
program in nanomedicine that aims to produce a new, hybrid generation of
physician researchers. Dr. Brenner is both personally and professionally
dedicated to health and wellness and practices what she preaches by
participating in fitness events including road, trail, and snowshoe races
ranging from 1 km sprints to 50 mile ultramarathons. She is the recipient of
the Albany-Colonie Chamber of Commerce Women of Excellence Award 2012
(Emerging Professional). Brenner Research Team website: https://sunypoly.edu/research/team-brenner/
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Feb. 4 |
Host:
Anthony Muscat, Chemical and Environmental Engineering, The University of
Arizona
Presented
by: James Lawrence
Hackett IV, Chemical and Environmental Engineering, The University of
Arizona
Topic title: “Investigation
of Speciation in III‐V Wet Etching to Mitigate Hazardous Product Formation”
Abstract:
As semiconductor manufactures continue
to look into the possible roles of III-V materials, more work is needed to
determine the environmental and health impacts of large scale manufacturing.
This work aims to measure this impact by taking a mass balance approach,
looking at the speciation across liquid, gas, and solid phases. The analysis
will be guided by thermodynamic software: Phreeqci and STABCAL. To
demonstrate the mass balance, experiments consisting of wet etching GaAs
(100) in 0.03% (v/v) HF were performed. The etching resulted in a Ga:As
molar ratio of 100:1 in the aqueous phase using ICP-MS. Under these
conditions, it is possible that AsF3 is forming and then leaving
the solution. Also, a STABCAL demonstration shows the construction of
potential-pH diagrams for citric acid systems.
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Mar. 3 |
Host: Shyam
Aravamudhan, Joint School of Nanoscience and Nanoengineering, North Carolina
A&T State University and University of North Carolina at Greensboro
Presented by: Steven Crawford, Graduate Student, Joint
School of Nanoscience and Nanoengineering, North Carolina A&T State
University and University of North Carolina at Greensboro
Topic title: "Update
on Physicochemical Characterization and Toxicity Analysis of Spent CMP
Waste"
Abstract: This talk will report on the current progress
in understanding of physicochemical characteristics and preliminary toxicity
of pristine CMP slurries and spent CMP waste following polishing of GaAs and
HDP oxide films. GaAs and HDP oxide films were polished under different CMP
conditions using slurries containing colloidal or fumed silica nanoparticles.
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April 7 |
No Seminar -- ERC Review
Meeting |
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May 5 |
Host: Jane
Chang, Department
of Chemical and Biomolecular Engineering,
University of California-Los Angeles
Presented by: Jane Chang, University of
California-Los Angeles
Topic title: "The Challenges and Opportunities of Atomic Layer
Etching"
Abstract:
The introduction of new and functionally
improved materials into silicon based integrated circuits is a major driver
to enable the continued down-scaling of circuit density and performance
enhancement in analog, logic, and memory devices. Many new materials, such
as multiferroics, magnetic materials and phase change materials, are much
harder to pattern, thereby posing significant challenges to the design and
selection of plasma etching chemistry. While ion milling is effective in
patterning some of these functionally improved materials, such as complex
magnetic material stacks used in magnetic tunnel junctions, it limits the
scalability and integration of devices. These challenges point to the
growing needs of identifying and developing viable etch chemicals and
processes that are more effective in patterning complex materials and
material systems.
In this talk, a generalized approach based on combined
thermodynamic assessment and kinetic validation is presented to identify and
validate the efficacy of various plasma chemistries. Specifically,
potential reactions between the dominant vapor phase/condensed species at
the surface are considered at various temperatures and reactant partial
pressures. The volatility of etch product was determined to aid the
selection of viable etch chemistry leading to improved etch rate of reactive
ion etching process. Based on the thermodynamic screening, viable
chemistries are tested experimentally to corroborate the theoretical
prediction. Some of the above mentioned material systems such as
magnetic materials used in magnetic tunnel junctions are used as examples to
demonstrate the broad applicability of this approach.
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June 2 |
Host: Paul Westerhoff,
Professor in the Civil, Environmental and Sustainable Engineering Program in
the School of Sustainable Engineering and the Built Environment, Ira A.
Fulton Schools of Engineering (FSE), Arizona State
University
Presented by: Jared Schoepf, PhD Candidate, Arizona
State University
Topic title:
“Detection of engineered nano materials in complex matrices: A case study on
nano materials in Food”
Abstract:
The
unknowns surrounding presence, composition and transformations during the
use phase of engineered nanoparticles (ENPs) in consumer products is raising
human and environmental health concerns. This research developed evidence
and confirmatory analytical methods to determine the presence and
composition of ENPs in consumer products with a complex organic matrix.
Three methods were developed to analyze three different sets of food
products. Processed foods such as taco seasoning, cake powders, vitamins,
and candies (N=28) were analyzed for the absence or presence of silicon and
titanium dioxide. Silicon dioxide is used as an anticaking agent and
texturizer while titanium dioxide is used as a white pigment. Laser Induced
Breakdown Spectroscopy (LIBS) was used as a pre-screening technique with
presence confirmed by transmission electron microscopy (TEM) and
concentration measured by inductively coupled plasma – mass spectroscopy (ICP-MS).
TEM confirmed 25 food samples with the presence of either nano silicon
dioxide (aprox. 20 nm in diameter), or nano titanium dioxide (aprox. 130 nm
in diameter). Vegetables and fruits (N=17) were analyzed for coatings with
nanomaterial presence with scanning electron microscopy (SEM). SEM confirmed
the absence of engineered nanomaterials. Baby formulas (N=6) were analyzed
for nano-hydroxyapatite using x-ray fluorescence (XRF) and TEM. Nano-scale
crystalline needle-shaped hydroxyapatite (HA; appx. 25 nm x 150 nm) primary
particles, present as aggregates (0.3-2 μm), were detected in half the
samples. Dissolution experiments with needle-shaped HA were conducted to
assess potential transformations in simulated drinking water (near-neutral
pH) and simulated biological fluids (saliva and acidic gastric fluids).
We conclude that LIBS or XRF alone or in combination with sample
pre-treatment techniques provides a rapid, field deployable technique to
detect nanomaterials in complex matrices that is faster than TEM or ICP-MS
analysis. This approach will aid human exposure assessments to food products
but could also be applied to swabs, fabrics, or biological fluids or tissues
to rapidly screen for potential nanomaterial exposure.
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July 7 |
No
Seminar |
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Aug.
4 |
Host: Rockford Draper,
Ph.D., Department of Biological Sciences, University of Texas-Dallas
Presentation by:
Vasanth Murali, Ph.D.,
Department of Biological Sciences, University of Texas-Dallas
Topic title:
"The Impact of Subcellular Location on the Near Infrared-Mediated
Thermal Ablation of Cells by Targeted Carbon Nanotubes"
Abstact: Single-walled carbon nanotubes (SWNTs) are used in
the near infrared (NIR)-mediated thermal ablation of tumor cells because
they efficiently convert absorbed NIR light into heat. Despite the
therapeutic potential of SWNTs, there have been no published studies that
directly quantify how many SWNTs need be associated with a cell to achieve a
desired efficiency of killing, or what is the most efficient subcellular
location of SWNTs for killing cells normalized to the dose of SWNTs in that
location. Herein we measured dose response curves for the efficiency of
killing correlated to the measured amounts of folate-targeted carboxylated
SWNTs that were either on the surface or within the vacuolar compartment of
normal rat kidney (NRK) cells. The SWNT subcellular locations were verified
using Raman imaging of SWNTs merged with fluorescence imaging of known
subcellular markers. The dose response curves revealed that 3.5 pg/cell of
SWNTs confined to the cell surface had little effect on cells upon NIR
irradiation under the standard conditions used. However, when 3.5 pg/cell of
SWNTs were internalized within endosomal/lysosomal compartments, ~50% of the
cells were killed after NIR exposure. To our knowledge, this is the first
time that SWNT amounts at known subcellular locations have been correlated
with a dose-normalized efficacy of thermal ablation and the results support
the idea that SWNTs confined to the plasma membrane are not as effective in
NIR-mediated cell killing
as an equivalent
amount of SWNTs within the endosomal/lysosomal vesicles.
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Sept. 1 |
Host:
Farhang Shadman, Chemical and Environmental Engineering, University of
Arizona
Presented by: Prof. Roberto Guzman, Chemical and
Environmental Engineering, University of Arizona
Topic title:
Synthesis and Study of Chelating
Polymers and Their Application to Metal Ion Separations: Regenerable
Chelating Adsorbents for Effective Removal of Arsenic from Aqueous Solutions
Abstract:
In
this presentation, we will describe the use of derivatives of
polyethylenimine (PEI)-polymer-chelates and their use as new chelating
hydrogels for metal ion separations. Metal ions, being electrophiles, have
propensity to combine with nucleophiles to form metal complexes. The
chelated metal ions serve as selective adsorption centers for specified
nucleophiles used here for the synthesis of reversible and regenerable
arsenic adsorbents. The significance of this method is that there is no need
for disposal of the adsorbent since this new media can be re-generated
indefinitely without a decrease in their capacity or effectiveness. In this
approach, a modified polymer (a chelating branched carboxylated
polyethylene-imine, CM-PEI) with high capacity for metal ions (e.g., Fe(III),
Cu(II)) is attached covalently to a solid matrix. Once the Fe(III) ion is
chelated, as an example, the immobilized metal has high affinity and high
capacity for arsenate ions. The adsorbed arsenic is desorbed from the column
by simply decreasing the pH of the eluant solution and recovered in a highly
concentrated form. In this case however, the adsorbent column remains intact
and can be regenerated and there is no need to dispose of the media in a
landfill. Once the column is re-equilibrated with iron at an appropriate pH
(now as a regenerated adsorbent) it is ready again to start a new arsenic
adsorption-desorption cycle. The mechanism of adsorption in this proposed
case is the same mechanism involved in the adsorption of arsenic by
iron-based oxide systems, the most common adsorption of arsenic technique
used and recommended by the EPA, but in our scheme, the process of
adsorption is reversible and thus the adsorbent regenerable.
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Oct. 6 |
No Seminar
>> ERC-SRC Mid-Year Review (WebEx) |
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Nov. 3 |
Host: Anthony Muscat,
Dept. of Chemical and Environmental Engineering, University of Arizona
Presented by: Adam Hinckley, Ph.D. Student, Dept. of
Chemical and Environmental Engineering, University of Arizona
Topic title:
"Closing Mass Balances Through Speciation of
III-V Etching Products"
Abstract:
III-V materials
offer a pathway to advancing finFET device development because they possess
higher carrier mobility than Si or Ge. Wet chemical cleaning and patterning
of III-Vs produces soluble species that can remain in the liquid phase,
become solids or evaporate as gases. Because etching products contain such
elements as As, In, and Sb, they can pose serious health risks during
industrial wafer processing. Gas phase species were measured using a mass
spectrometer system designed to sample vapor at atmospheric conditions. Gas
phase species were detected above inorganic solutions used to etch GaAs, SiO2,
and InP. Using the detected signal for N2 as a reference,
the total concentration of As in the gas phase above 49 % (v/v) and 1% (v/v)
aqueous HF solutions was calculated to be approximately 2 ppm and 1 ppm,
respectively. Using the concentration calculated above 1 % (v/v) HF, an As
mass balance can be closed to within approximately 1 nmol. Additional work
will focus on closing mass balances to improve our understanding of III-V
etching mechanisms and identify safe industry-scale processing conditions.
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Dec. 1 |
Host: Shyam
Aravamudhan, Joint School of Nanoscience and Nanoengineering, North Carolina
A&T State University
Presented by:
Steven Crawford, Graduate
Student, Joint School of Nanoscience and Nanoengineering, North Carolina A&T
State University and University of North Carolina at Greensboro
Topic title:
"Update on characterization and
toxicity studies with bound (as composite filler) and unbound nanoparticles
(in CMP slurry)"
Abstract:
This talk will provide an
update on studies performed to understand the physical and chemical
characteristics of (a) composite filler material, namely boron nitride
nanoparticles before and after thermal degradation and (b) pristine slurries
and spent CMP waste after polishing of GaAs and HDP oxide films. Next, we
will discuss our preliminary determination of half maximal inhibitory
concentration (IC50) from the dose-response curves with both pre- (pristine)
and post (transformed) nanoparticles.
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Jan. 5, 2017
Happy New Year! |
No Seminar |
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Feb. 2 |
Host: Paul
Westerhoff,
Professor in the Civil, Environmental and Sustainable Engineering Program in
the School of Sustainable Engineering and the Built Environment, Ira A.
Fulton Schools of Engineering (FSE), Arizona State
University
Presented by: Michael Simonich, Ph.D., Faculty Research
Associate, Sinnhuber Aquatic Research Laboratory, Oregon State University
Topic title: "Using Multidimensional Zebrafish Data to
Advance Environmental Health"
Abstract:
Some environmental exposures to chemicals, drugs, and nanomaterials
negatively impact human and environmental health. The toxic entities
interact with “genomes” to cause harm. We can use high throughput in vivo
bioactivity assays to identify all hazardous agents. Phenotypic anchoring of
structures to omics results can be used to identify the “targets” of these
chemicals. Using structural and mechanistic information we can predict the
toxicity of novel materials, so it should be possible to proactively design
inherently safer products.
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Thursday
Feb. 2, 2017 |
Host: Paul
Westerhoff,
Professor in the Civil, Environmental and Sustainable Engineering Program in
the School of Sustainable Engineering and the Built Environment, Ira A.
Fulton Schools of Engineering (FSE), Arizona State
University
Presented by: Michael Simonich, Ph.D., Faculty Research
Associate, Sinnhuber Aquatic Research Laboratory, Oregon State University
Topic title: "Using Multidimensional Zebrafish Data to
Advance Environmental Health"
Abstract:
Some environmental exposures to chemicals, drugs, and nanomaterials
negatively impact human and environmental health. The toxic entities
interact with “genomes” to cause harm. We can use high throughput in vivo
bioactivity assays to identify all hazardous agents. Phenotypic anchoring of
structures to omics results can be used to identify the “targets” of these
chemicals. Using structural and mechanistic information we can predict the
toxicity of novel materials, so it should be possible to proactively design
inherently safer products.
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Thursday
March 2, 2017
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Host:
Reyes Sierra, Professor,
Chemical and Environmental Engineering, University of Arizona
Presented by: Chao Zeng,
Ph.D., Chemical and Environmental Engineering, University of Arizona
Topic title: "Impacts
of CMP nanoparticles on the cytotoxicity of soluble III/V species to human
lung cells"
Abstract:
Planarization of III/V
thin films can potentially result in the release of soluble arsenic, indium
and gallium species into CMP effluents. This work investigated the
cytotoxicity of soluble III/V species to 16HBE14o- human lung bronchial
epithelial cells in the presence and absence of engineered nanoparticles
commonly used in CMP processes (fumed SiO2, precipitated SiO2,
CeO2 and Al2O3). Cytoxicity assessment was
performed using a high throughput, impedance-based real-time cell analyzer (RTCA)
test system. The results obtained demonstrated that trivalent indium and
gallium displayed low toxicity compared to inorganic arsenic species (e.g.,
arsenite and arsenate). Furthermore, results showed that adsorption of
soluble III/V species onto the surface of CMP nanoparticles can affect their
fate, bioavailability and toxicity.
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Thursday
April 6th
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No Seminar/eWorkshop
Annual Review Meeting and ESH Workshop
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Thursday
May 4th
|
Special
post-review e-workshop
All
future seminars 'on hold'. SRC reviewing 'how' SRC/ERC will continue these presentations.
******************************
Note: To connect to
audio of the presentation, you must register in advance
for each e-Workshop using the 'current presentation' link posted above.
Once registered (direction below), you will receive a
confirmation-of-registration email from SRC. Prior to day
of presentation, you will receive another SRC email which will give you the
current presentation's URL link,
WebEx audio connection information, and PDF presentation
connection.
SRC online
registration:
If you have previously registered with SRC and have a user name and
password, click on e-Workshop link, enter user name/password information,
then click on "Submit registration."
*** If you do not have a SRC
log-in account, you must register on line; it's a free, fast, and one-time
registration process. Click on the e-Workshop link then, to obtain a
user name/password, click on: “Don’t have an account” and
fill in information as requested.
_______________________________________________
If you should experience problems with any portion of the registration
process, WebEx link and/or audio connection on the day of presentation, or
have any questions, please contact: Mary Altman,
Semiconductor Research Corporation
Phone: 919-941-9448
Email:
Mary.Altman@src.org
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Thursday
June 1st
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Host: Andre
Nel, University of California-Los Angeles
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Thursday
July 6th
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Host:
Anthony Muscat/Srini Raghavan, University of Arizona |
Thursday
August 3rd
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Host: Shyam
Aravamudhan, NCAT |
Thursday
Sept. 7th
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Host: Paul
Pantano/Rockford Draper, University of Texas-Dallas |
Thursday
October 5th
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No TeleSeminar--MidYear Review/WebEx |
Thursday
November 2nd
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Host:
Farhang Shadman, University of Arizona |
Thursday
December 7th
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(Open) |
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END OF CURRENT PROJECTS CONTRACT |
January
2018 |
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